Barn og ungdom Barn beneath eighteen år skal ikke ta dette legemidlet. Andre legemidler og Modiodal: Snakk med lege eller apotek dersom du bruker, nylig har brukt eller planlegger å bruke andre legemidler. Modiodal og visse andre legemidler kan påvirke hverandre, og legen din kan trenge å justere dosene du tar.
Nedsatt konsentrasjon av ciklosporin (fifty % i en kasuistikk; ingen details foreligger fra mer sytematiske studier)
This medicine isn't going to take the spot of having enough rest. It should not be utilized for occasional sleepiness which has not been diagnosed as narcolepsy, snooze apnea, or shift function slumber challenges. Inquire your medical doctor for suggestions about superior sleep behavior.
Modafinil could cause skin reactions that may be serious ample to wish treatment in a very medical center. Halt getting this drugs and obtain crisis health care assistance In case you have:
convey to your doctor and pharmacist what prescription and nonprescription medicines, natural vitamins, nutritional nutritional supplements, and herbal goods you might be using or intend to get whilst having modafinil. Your health care provider might need to alter the doses within your medications or observe you diligently for Unwanted side effects.
Could minimize effectiveness of steroidal contraceptives a person thirty day period soon after discontinuation of drug therapy
Be sure you know how you react to this medicine before you drive, use equipment, or do other Employment that demand you to be warn, properly-coordinated, or able to Assume or see nicely.
Behandling skal initieres av eller beneath tilsyn av lege med tilstrekkelig erfaring i diagnostisering og behandling av narkolepsi.
Investigate suggests that modafinil is corresponding to amphetamine during the cure of ADHD.[26] Even though it is currently in some cases applied instead to conventional stimulants for that procedure of adult ADHD, it really is at this time not approved like a treatment method for childhood ADHD.
There have been two reports released by Randall et al that confirmed little if any significant effect of modafinil on neurocognitive exam general performance in healthy folks (Randall et al 2003, 2004), but a afterwards evaluation performed by this group on their own exploration confirmed that modafinil did increase neurocognitive performance in normal IQ topics although not superior IQ topics (Randall et al 2005). The authors concluded that this means that modafinil has limited cognitive improving consequences in now high-doing very well-rested persons, but they didn't consider ceiling consequences in neurocognitive assessments made to evaluate cognitive impairment as many of the other scientific tests did (Turner et al 2003; Muller et al 2004).
In animal experiments, the median lethal dose (LD50) of modafinil varies among the species and depends upon the route of administration. In mice and rats, the LD50 is somewhere around 1250 mg/kg if administered via an injection, although the oral LD50 for rats is 3400 mg/kg.
An overdose of modafinil may lead to a range of signs and symptoms and complications. Psychiatric signs may incorporate psychosis, mania, hallucinations, and suicidal ideation, which can happen even in men and women without having a history of mental sickness and will persist soon after discontinuation of your drug.
To be able to get a prescription for modafinil, a affected person should have get more info a sound clinical basis for using the drug, which include narcolepsy or obstructive rest apnea. Furthermore, the prescription must be penned by a licensed health practitioner and stuffed in a accredited pharmacy. The use of modafinil for non-professional medical reasons, for example Using the intention to boost cognitive overall performance or to stay awake for prolonged amounts of time, is strictly prohibited and may result in lawful penalties.[184][185]
We located only two neuroimaging research analyzing the consequences of modafinil (Ellis et al 1999; Spence et al 2005) the two of which applied BOLD fMRI to observe celebration-associated circulatory improvements within the brain. These two experiments are extremely diverse inside their technique and population, but they each showed that modafinil appears to modulate instead of unilaterally alter event-associated cortical blood stream adjustments, for in both of those scientific studies modafinil’s effect on function-related cortical blood move modifications is negatively correlated to baseline function-related cortical blood circulation improve. Notably, the research involving schizophrenic subjects calculated party associated alterations in a very Operating memory activity, when the analyze evaluating narcoleptic and typical subjects measured function-linked changes through sensory stimulation.